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Final Report/Thesis 2018
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====Heritage==== The first task completed was investigating the heritage of the DNA sample sent. There were various genetic ancestry projects that could have been chosen, therefore research was completed on all the different genetic ancestry projects to make sure that the results would be the most accurate. Eurogenes seemed the most appropriate considering the sample is decent of European background. The next part was to select which model was most appropriate to calculate the heritage in the DNA, again significant research was completed and the chosen model was Eurogenes K13, as this model is best for samples with mixed heritage. The heritage results for the original case (no SNPs removed) can be seen in Figure 30, it can be seen that the sample has strong heritage in North Atlantic, Baltic and West Mediterranean regions. [[File:soFigure30.jpg|thumb|500px|center|Figure 30. Heritage results]] The results that were completed only took consideration of North Atlantic and Baltic regions as these had the highest percentages, 29.13% and 42.11% respectively. The other cases were than completed, the 10%-90% of SNP removal. A graph was produced to visualise what was happening when removing the SNPs, which can be seen in Figure 31. [[File:soFigure31.jpg|thumb|500px|center|Figure 31. Heritage test, with SNPs removed]] The x-axis represents how much SNP is removed in the sample and the y-axis is how much percentage of that heritage the sample is. Observing the graph it can see the results are relative steady up to about 60%, the results then fluctuate at 70% and onwards. This indicates that removing more than 70% of the SNPS will result in inaccurate results. This result is not enough to conclude this, so five more tests were completed to see if the trend was similar for each case. The figure below demonstrates the average of the heritage tests completed. [[File:soFigure32.jpg|thumb|500px|center|Figure 32. Average of the Heritage Test]] It can be seen that average results are all relatively linear, expect for some points at North Atlantic 40%, 80% and 90% and Baltic 80% and 90%. The error bars however, get larger as the percentage of SNPs are being removed. This indicates that the DNA samples start to lose its structure as SNPs are being removed. From 10%-40% of SNP removed, the standard deviation starts increasing to approximately 1, which shows the DNA is still robust. From 50%-90% of SNP removed, the results starts to vary significantly, which shows as the error bars are large and the standard deviation is much larger. It can be concluded with these results that DNA sample is robust until about 50% and after that DNA becomes unidentifiable.
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